PARK2 (G12) pAb

Parkin is a zinc-finger protein that is related to ubiquitin at the amino terminus. The wild type Parkin gene, which maps to human chromosome 6q25.2- 27, encodes a 465 amino acid full-length protein that is expressed as multiple isoforms ranging from 50-58 kDa. Mutations in the Parkin gene are responsible for utosomal recessive juvenile Parkinson's disease and commonly involve deletions of exons 3-5. In humans, Parkin is expressed in a subset of cells of the basal ganglia, midbrain, cerebellum and cerebral cortex, and is subject to alternative splicing in different tissues. Parkin expression is also high in the brainstem of mice, with the majority of immunopositive cells being neurons. The Parkin gene has been identified in a diverse group of organisms including mammals, birds, frog and fruit flies, suggesting that analogous functional roles of the Parkin protein may have been highly conserved during the course of evolution

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SPECIFICATIONS

Catalog Number

BS1284

Size

100ug/100ul

Applications

IF, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 1-50 of Human PARK2.

Species

Parkin (G12) pAb detects endogenous levels of Parkin protein.

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200\nIF: 1:50~1:200

Swiss Prot

O60260

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 52 kDa

Alternative Names

AR JP; \nE3 ubiquitin ligase; \nE3 ubiquitin protein ligase parkin; \nE3 ubiquitin-protein ligase parkin; \nFRA6E; \nLPRS 2; \nLPRS2; \nPARK 2; \nPark2; \nParkin 2; \nParkinson disease (autosomal recessive juvenile) 2; \nParkinson disease protein 2; \nParkinson juvenile disease protein 2; \nParkinson protein 2 E3 ubiquitin protein ligase; \nPDJ; \nPRKN 2; \nPRKN; \nPRKN2; \nPRKN2; \nUbiquitin E3 ligase PRKN; \n