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Patched (A2) Peptide

Cat no: BS1286P

Patched (A2) Peptide

PTCH (Patched protein homolog 1) is a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). PTCH associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.PTCH has a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. PTCH is expressed in the adult brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. It is also expressed in tumor cells but not in normal skin. During development PTCH is found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud. \nDefects in PTCH are probably the cause of basal cell nevus syndrome also known as Gorlin syndrome or Gorlin-Goltz syndrome

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SPECIFICATIONS

Catalog Number

BS1286P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide Patched (A2). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q13635

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1286 Patched (A2) pAb.

Alternative Names

PTCH1

SUPPLIER INFO

Bioworld Technology, Inc.

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