PCAF (F820) Peptide

Cat no: BS1417P

Supplier: Bioworld Technology, Inc.

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In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAFII p250. Mammalian HDAC1 (also designated HD1) and HDAC2 (also designated mammalian RPD3), both of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.

Catalogue number:	BS1417P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q92831
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide PCAF (F820). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	PCAF; Histone acetylase PCAF; EC 2.3.1.48; P300/CBP-associated factor; P/CAF; PCAF; CREBBP associated factor Histone acetylase PCAF p300/CBP associated factor
Additional info:	This peptide can be used with studies using BS1417 PCAF (F820) pAb.

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PCAF (F820) Peptide

Cat no: BS1417P

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