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PDE4B/C/D (H47) pAb

PDE4B/C/D (H47) pAb

Cat no: BS1572

Supplier: Bioworld Technology, Inc.
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Phosphodiesterases (PDE) hydrolyze cAMP to 5'AMP and thus play a critical role in the regulation of intracellular cAMP. Division of the PDE superfamily by sequence homology and enzymatic properties yields 11 PDE families. A unique upstream conserved region (UCR) characterizes the PDE4 family. Four separate genes (A-D) encode the PDE4 enzymes, and alternative splicing generates short or long isoforms of each gene. Long PDE4 isoforms contain both UCR1 and UCR2 while short PDE4 isoforms possess only UCR2. Both UCR domains are necessary for dimerization of PDE4 isoforms. The human PDE4D gene maps to chromosome 5q12. The splice variants include isoforms PDE4D1-6.
Catalogue number: BS1572
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: Q08499/Q07343/Q08493
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to the N-terminus of Human PDE4B/C/D.
Species: PDE4B/C/D (H47) pAb detects endogenous levels of PDE4B/C/D protein.
Molecular weight: ~88 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: cAMP-specific 3',5'-cyclic phosphodiesterase 4B; DPDE4; PDE32; PDE4B; DPDE4; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; DPDE3; PDE43; DPDE3; cAMP-specific 3',5'-cyclic phosphodiesterase 4C; DPDE1; PDE21; PDE4C; DPDE1
Additional info: For research use only, not for use in diagnostic procedure.

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