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PDE4D pAb

PDE4D pAb

Cat no: BS6687


Supplier: Bioworld Technology, Inc.
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Phosphodiesterases (PDE) hydrolyze cAMP to 5'AMP and thus play a critical role in the regulation of intracellular cAMP. Division of the PDE superfamily by sequence homology and enzymatic properties yields 11 PDE families. A unique upstream conserved region (UCR) characterizes the PDE4 family. Four separate genes (A-D) encode the PDE4 enzymes, and alternative splicing generates short or long isoforms of each gene. Long PDE4 isoforms contain both UCR1 and UCR2 while short PDE4 isoforms possess only UCR2. Both UCR domains are necessary for dimerization of PDE4 isoforms. The human PDE4D gene maps to chromosome 5q11.2. The splice variants include isoforms PDE4D1-6.
Catalogue number: BS6687
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: Q08499
Dilutions: WB: 1:500~1:2000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Recombinant full length Human PDE4D.
Species: PDE4D pAb detects endogenous levels of PDE4D protein.
Molecular weight: ~ 91 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: cAMP-specific 3',5'-cyclic phosphodiesterase 4D; DPDE3; PDE43; DPDE3
Additional info: For research use only, not for use in diagnostic procedure.

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