PEDF (T307) Peptide

Pigment epithelium derived factor, originally identified in conditioned medium of cultured human fetal retinal pigment epithelial (RPE) cells, is a neurotrophic protein that induces extensive neuronal differentiation in human Y79 retinoblastoma cells, a neoplastic counterpart of normal retinoblasts. It has been suggested that PEDF is synthesized by RPE cells and secreted into the retina interphotoreceptor matrix where it may influence development/differentiation of the neural retina. PEDF is a potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The PEDF gene is a member of the serpin gene family. Serpins are a group of serine protease inhibitors, some of which have also been reported to exhibit neurotrophic activity.

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SPECIFICATIONS

Catalog Number

BS2842P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide PEDF (T307). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P36955

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS2842 PEDF (T307) pAb.

Alternative Names

Cell proliferation-inducing gene 35 protein; EPC 1; EPC-1; EPC1; PEDF; PEDF; PIG 35; PIG35; Pigment epithelium derived factor; Pigment epithelium-derived factor; Proliferation inducing protein 35; Serpin F1; Serpin peptidase inhibitor clade F member 1; SERPINF 1; Serpinf1;