Peptide YY (PYY, Peptide Tyrosine Tyrosine) (BSA & Azide Free)

Neuropeptide Y (NPY), a neuropeptide colocalized and abundantly released with the neurotransmitter norepinephrine in nervous system, synthesized by postnatal olfactory epithelium of sustentacular cells. It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. NPY a 97aa peptide in mouse, human (chr 7p15.1) and 98aa in rat has a mol. wt of 11kD. NPY shows sequence homology to Peptide YY (PYY) and over 50% homology in amino acid and nucleotide sequence to Pancreatic Polypeptide (PNP or PPY), all of these homologous peptides has a 36aa mature peptide characterized by a hairpin loop. \nPYY: Secreted as 97aa precursor from endocrine cells in the lower small intestine, colon, and pancreas. It acts on the gastrointestinal tract as an inhibitor of gastric acid secretion, gastric emptying, and digestive enzyme secretion by the pancreas, and gut motility.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/ml. See P3285-11A.\nWestern Blot: 1-10ug/ml using ECL technique.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P3285-11B

Size

50ug

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.2. No stabilizing proteins added. No preservative added. Also available with BSA & Azide. See P3285-11.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

Batterham R. L et al (2002) Nature 418: 650-653; Hort Y. Baker (1995) Genomics 26: 77-83; Thiele, T. E et al (1998) Nature 396: 366-369; Maccarrone C. D et al (1986) Neurochem. Int 8: 13-22.

Additional Info

Recognizes mouse PYY.