Peripheral Myelin Protein 22 (PMP22, Growth arrest-specific protein 3, Gas-3)

Myelin protein zero (P0) is the most abundant protein in mammalian peripheral nerve myelin. An interaction between P0 and PMP22 has been detected in compact myelin. Defects in PMP22 have been related to Charcot-Marie-Tooth disease (CMT) and inflammatory demyelinating neuropathy (IDP). Immunization with PMP22 induces experimental auto-immune neuritis without central nervous inflammation. Therefore, PMP22 is considered as candidate auto-antigen in inflammatory diseases of the peripheral nervous system, including both acute and chronic inflammatory demyelinating polyradiculoneuropathy. \n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry and ELISA. Other aplications not tested.\n\nRecommended Dilutions:\nWestern Blot: 1:50\nImmunohistochemistry: Paraffin embedded sections\nOptimal dilutions to be determined by researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P4305-05

Size

100ug

Applications

ELISA, IHC, WB

Hosts

Mouse

Reactivities

Hum, NHP

Form

Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

1. Gregson, N et al; Characterization of a monoclonal antibody specific for human peripheral myelin protein 22 and its use in immunohistochemical studies of the fetal and adult nervous system. J Peripher Nerv Syst 2007, 12: 2.

Additional Info

Recognizes human peripheral myelin protein 22 (PMP22). Species Crossreactivity: Rhesus monkey.

Alternative Names

Peripheral Myelin Protein 22, Growth arrest-specific protein 3, Gas-3