Peripherin

Human Perpherin is a 53.651kD (470 aa) expressed in all PNS neurons and some CNS neurons, including a subset of cortical neurons, hippocampal neurons, and ventral horn spinal cord motor neurons. At an ultrastructural level, peripherin immunoreactivity is associated with the neurofilament portion of the cytoskeleton, being particularly abundant in the cell body. Peripherin protein has been shown to undergo upregulation during periods of trophic stress in cultured neurons, and mutations of the peripherin gene have been associated with the neurodegenerative disease amyotrophic lateral sclerosis.\n\nApplications:\nSuitable for use in Immunohistochemistry, Immunocytochemistry and Western Blot. Other applications have not been tested. \n\nRecommended Dilutions: \nImmunohistochemistry: 1:2000-1:5000 using 2% paraformaldehyde tissues\nImmunocytochemistry: 1:2000-1:5000 using 2% paraformaldehyde cells\nWestern Blot: 1:5000-1:10,000\nOptimal dilutions to be determined by the researcher. \n\nRecommended Secondary Antibodies:\nI1906 IgY, Chicken Pab Rb x Ch \nI1906-10 IgY, Chicken (HRP) Rb x Ch \nI1906-12 IgY, Chicken (FITC) Rb x Ch \nI1906-14 IgY, Chicken (AP) Rb x Ch\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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