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PERK (R87) pAb

PERK (R87) pAb

Cat no: BS2156


Supplier: Bioworld Technology, Inc.
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An interferon-inducible, RNA-dependent protein serine /threonine kinase (PKR) has been described. PKR in earlier literature is variously known as DAI, dsJ, PI kinase, p65, p67 or TIK for the mouse kinase; and p68 or p69 for the human kinase. The PKR kinase substrate is the (alpha) subunit of protein synthesis initiation factor eIF-2. Phosphorylation of eIF-2(alpha) on serine-51 results in inhibition of translation. The serine /threonine kinase catalytic domains map to the carboxy terminal half of the protein while the RNA-binding domains are located in the amino terminal region. PERK is a type I transmembrane protein located in the endoplasmic reticulum (ER) that contains a kinase domain similar to the kinase domain of PKR. PERK is activated in response to ER stress and phosphorylates eIF-2(alpha), thus inhibiting the translation of mRNA.
Catalogue number: BS2156
Reactivities: Human
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: Q9NZJ5
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 56-102 of Human PERK.
Species: PERK (R87) pAb detects endogenous levels of PERK protein.
Molecular weight: ~125 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: EIF2AK3; DKFZP781H1925; EC 2.7.11.1; HSPEK; PEK; PERK; WRS
Additional info: For research use only, not for use in diagnostic procedure.

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