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PERK (R87) Peptide

Cat no: BS2156P

PERK (R87) Peptide

An interferon-inducible, RNA-dependent protein serine /threonine kinase (PKR) has been described. PKR in earlier literature is variously known as DAI, dsJ, PI kinase, p65, p67 or TIK for the mouse kinase; and p68 or p69 for the human kinase. The PKR kinase substrate is the alpha subunit of protein synthesis initiation factor eIF-2. Phosphorylation of eIF-2alpha on serine-51 results in inhibition of translation. The serine /threonine kinase catalytic domains map to the carboxy terminal half of the protein while the RNA-binding domains are located in the amino terminal region. PERK is a type I transmembrane protein located in the endoplasmic reticulum (ER) that contains a kinase domain similar to the kinase domain of PKR. PERK is activated in response to ER stress and phosphorylates eIF-2alpha, thus inhibiting the translation of mRNA.

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SPECIFICATIONS

Catalog Number

BS2156P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide PERK (R87). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q9NZJ5

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS2156 PERK (R87) pAb.

Alternative Names

EIF2AK3; DKFZP781H1925; EC 2.7.11.1; HSPEK; PEK; PERK; WRS

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