The Peroxin gene family, which includes more than 20 members, is required for peroxisome biogenesis. Peroxin 10 (Peroxisome biogenesis factor 10), also known as RNF69 (RING finger protein 69), is a 326 amino acid protein that exhibits E3 ligase activity in vitro, suggesting that it is involved in Ubc4-dependent ubiquination. Defects in the gene encoding Peroxin 10 are the result of a number of different disorders, such as Peroxisome biogenesis disorder complementation group 7, Zellweger syndrome and adrenoleukodystrophy neonatal. There are two isoforms of Peroxin 10 that are produced as a result of alternative splicing events.