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PF 477736

PF 477736

Cat no: 019317

Supplier: United States Biological
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Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Pfizer Compound
Catalogue number: 019317
Size: 10mg
Alternative names: (aR)-a-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]cyclohexaneacetamide;
References: Ashwell, et al.: Clin. Cancer Res., 14, 4032 (2008); Blasina, et al.: Mol. Cancer Ther., 7 2394 (2008); Zhang, et al.: Clin. Cancer Res., 15 4630 (2009);

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