Home  >  Products  >  PHLPP2 (PH Domain Leucine-rich Repeat-containing Protein Phosphatase 2, KIAA0931, PH Domain Leucine-rich Repeat-containing Protein Phosphatase-like, PHLPP-like, PHLPPL)
PHLPP2 (PH Domain Leucine-rich Repeat-containing Protein Phosphatase 2, KIAA0931, PH Domain Leucine-rich Repeat-containing Protein Phosphatase-like, PHLPP-like, PHLPPL)

PHLPP2 (PH Domain Leucine-rich Repeat-containing Protein Phosphatase 2, KIAA0931, PH Domain Leucine-rich Repeat-containing Protein Phosphatase-like, PHLPP-like, PHLPPL)

Cat no: P4070-88F

Supplier: United States Biological
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PHLPP2, a protein phosphatase and negative regulator, which mediates the inactivation of Akt and protein kinase C (PKC) activity, through the direct dephosphorylation of key regulatory sites: AKT1 (Ser473), PRKCA (Ser657) and PRKCB isoform beta-II (Ser660). PHLPP2, and its alternative isoform PHLPP1, have been implicated as important suppressors of tumour cell growth, being linked with breast, ovarian and colon cancer. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.1-0.3ug/ml, observed in human brain (amygdala, hippocampus, substantia nigra) lysates on ~140kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: P4070-88F
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell. 2005 Apr 1;18(1):13-24.
Additional info: Recognizes human PHLPPL.

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