Phosphatase, Alkaline, Bone (BALP, BAP, Alkaline Phosphatase Liver/bone/kidney, ALPL, AKP2, Alkaline Phosphatase Tissue Nonspecific Isozyme, Alkaline Phosphomonoesterase, AP-TNAP, FLJ40094, Glycerophosphatase, HOPS, Liver/bone/kidney Isozyme, PHOA, Tissue

Alkaline phosphatase (AP) is a ubiquitously expressed enzyme which removes phosphate groups from target molecules, including DNA, RNA and alkaloids, under alkaline conditions, and is present at higher concentrations in the placenta (placental AP), intestines (intestinal AP) and liver/bone/kidney (tissue non-specific AP). Although the exact biochemical function of BAP is uncertain, measurement of the serum levels of BAP can be used as a biochemical indicator of bone turnover. Conditions which present with a decrease in the level of BAP (hypophosphatasemia) include the inherited bone-deforming disorder hypophosphatasia and osteoporosis, while an increase in BAP (hyperphosphatasemia) is associated with Paget

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SPECIFICATIONS

Catalog Number

P4071-04E

Size

200ug

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.09% sodium azide.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1

Additional Info

Recognizes human alkaline phosphatase, a hydrolase enzyme most active at alkaline pH. Detects the tissue isotypes BAP, PLAP, and IAP (bone, placental and intestinal alkaline phosphatase), but may react with other alkaline phosphatases.