Phosphodiesterase 4A (Phosphodiesterase 4A cAMP-specific, Phosphodiesterase-4A, PDE4A, cAMP Specific 3

Cellular Localization: Cell Membrane\n\nApplications: \nSuitable for use in Immunofluorescence, Western Blot, Immunoprecipitation and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

P4072-03E

Size

100ug

Applications

ICC, IF, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Rabbit

Form

0.02% Thimerosal / Merthiolate

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

Zhang HT et al. Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism. Neuropsychopharmacology 23:198-204 (2000). <PUBMED:10882846>Yarwood SJ et al. The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform. J Biol Chem 274:14909-17 (1999). <PUBMED:10329691>Beavo JA Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev 75:725-48 (1995). <PUBMED:7480160>Farooqui SM et al. Antibodies against synthetic peptides predicted from the nucleotide sequence of D2 receptor recognize native dopamine receptor protein in rat striatum. J Neurochem 57:1363-9 (1991). <PUBMED:1832709>

Additional Info

This antibody labels all known PDE4A variants including PDE4A1 (66kD), A5 (109kD), A8 (106kD), Ax (102kD) and a 76kD testis specific A variant. Species Crossreactivity: Human, Mouse, Rat and Rabbit.