Phosphodiesterase Type 4D3 (PDE4D3, cAMP Specific 3' 5' Cyclic Phosphodiesterase 4D, cAMP Specific 3'5' Cyclic Phosphodiesterase 4D, cAMP Specific Phosphodiesterase 4D, cAMP Specific Phosphodiesterase PDE4D3, Dunce-like Phosphodiesterase E3, DPDE3, hPDE4D

Applications: \nSuitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

P4072-03P

Size

100ug

Applications

ICC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

0.02% Sodium Azide

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

Bolger GB et al. Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene. Biochem J 328 ( Pt 2):539-48 (1997). <PUBMED:9371713>Erdogan S & Houslay MD Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant. Biochem J 321 ( Pt 1):165-75 (1997). <PUBMED:9003416>Alvarez R et al. Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3. Mol Pharmacol 48:616-22 (1995). <PUBMED:7476886>

Additional Info

Recognizes PDE4D3. Does not crossreact with PDE4D1, D2, D4 and D5. Does not cross react with PDE4A, PDE4B or PDE4C. Species Crossreactivity: Human, Mouse and Rat.