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Phosphoinositide 3 Kinase, p110 alpha (PI3K, caPI3K, MGC142161, MGC142163, p110 alpha, p110-alpha, Phosphatidylinositol 3 Kinase Catalytic alpha Polypeptide, Phosphatidylinositol 3 Kinase Catalytic 110kD alpha, Phosphatidylinositol-4,5-bisphosphate 3-kina

Cat no: P4073-26K

Phosphoinositide 3 Kinase, p110 alpha (PI3K, caPI3K, MGC142161, MGC142163, p110 alpha, p110-alpha, Phosphatidylinositol 3 Kinase Catalytic alpha Polypeptide, Phosphatidylinositol 3 Kinase Catalytic 110kD alpha, Phosphatidylinositol-4,5-bisphosphate 3-kina

Phosphoinositol-3-kinases (PI3 Kinase, PI3K) are a family of lipid kinases that mediate many intracellular signaling responses in both physiological and pathophysiological states. PI3 Kinase is a heteroduplex with three classes (I, II, & III) of catalytic domain. The class I PI3 Kinases are made up of a p85 regulatory protein and a p110 catalytic domain. There are 4 isoforms of the class I p110 catalytic domains. Class I(A) include alpha, beta, gamma and class I(B) delta. They are activated downstream via receptor tyrosine kinases or G-protein coupled receptors. Once activated, PI3K generates phosphatidylinositol 3,4,5-trisphosphate (PIP3) from PIP2. It was later found that PTEN, a lipid phosphatase, acts opposite to PI3K by dephosphorylating PIP3, converting it to PIP2, thus de-activating the effects of PI3K. Increased levels of PIP3 in the cell leads to the activation of many key signaling regulators including Akt and PDK as well as calcium release. One of the primary roles of PI3K is its regulation of cell growth and cell metabolism. Both of these play a critical role in cancer as some believe that a tumor

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SPECIFICATIONS

Catalog Number

P4073-26K

Size

100ug

Applications

ELISA, IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Rat

Form

Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

Additional Info

Recognizes human PI3 Kinase p110 alpha. \nSpecies Crossreactivity: rat

Read more on Supplier website

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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