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PI3K p110(alpha)/PIK3CA pAb

PI3K p110(alpha)/PIK3CA pAb

Cat no: BS6052

Supplier: Bioworld Technology, Inc.
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The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
Catalogue number: BS6052
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P42336
Dilutions: WB: 1:500~1:2000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Recombinant full length Human PI3K p110(alpha).
Species: PIK3CA pAb detects endogenous levels of PIK3CA protein.
Molecular weight: ~ 110 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: PIK3CA; MGC142161; MGC142163; PI3K; p110-alpha; Phosphatidylinositol-4; 5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol-4; 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
Additional info: For research use only, not for use in diagnostic procedure.

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