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PI3K p110(alpha) (R519) pAb

PI3K p110(alpha) (R519) pAb

Cat no: BS3456

Supplier: Bioworld Technology, Inc.
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Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of 85 kDa (p85) and 110 kDa (p110) subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85(alpha) and p85(beta)), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110(alpha) and p110(beta) interact with p85(alpha), and p110(alpha) has also been shown to interact with p85(beta) in vitro. p110(delta) expression is restricted to white blood cells. It has been shown to bind p85(alpha) and (beta), but it apparently does not phosphorylate these subunits. p110(delta) seems to have the capacity to autophosphorylate. p110(gamma) does not interact with the p85 subunits. It has been shown to be activated by (alpha) and (beta)(gamma) heterotrimeric G proteins.
Catalogue number: BS3456
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P42336
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 500-550 of Human PI3K p110(alpha).
Species: PI 3-kinase p110(alpha) (R519) pAb detects endogenous levels of PI 3-kinase p110(alpha) protein.
Molecular weight: ~ 110 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: PIK3CA; MGC142161; MGC142163; PI3K; p110-alpha; Phosphatidylinositol-4; 5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol-4; 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
Additional info: For research use only, not for use in diagnostic procedure.

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