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PIASx (G24) pAb

PIASx (G24) pAb

Cat no: BS1466

Supplier: Bioworld Technology, Inc.
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The IL-6-type family of cytokines, which includes IL-6 as well as a number of similar cytokines and growth factors, plays a significant role in regulating gene activation, proliferation and differentiation. Transcription factors of the Stat family are known to be involved in this signal transduction pathway, undergoing phosphorylation, dimerization and translocation to the nucleus upon activation. PIAS 1, for protein inhibitor of activated Stat1 (also designated Gu/RNA helicase II binding protein), binds specifically to Stat1, blocking Stat1 DNA-binding activity and inhibiting Stat1-mediated gene activation. PIAS 1 also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS 3 similarly binds specifically to Stat3, blocking Stat3 DNA-binding activity and inhibiting Stat3-mediated gene activation.
Catalogue number: BS1466
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: O75928
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 1-50 of Human PIASx.
Species: PIAS2 (G24) pAb detects endogenous levels of PIAS2 protein.
Molecular weight: ~ 68 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: E3 SUMO-protein ligase PIAS2; Protein inhibitor of activated STAT2; Protein inhibitor of activated STAT x; Msx-interacting zinc finger protein; Miz1; DAB2-interacting protein; DIP; Androgen receptor-interacting protein 3; ARIP3; PIAS-NY protein; PIAS
Additional info: For research use only, not for use in diagnostic procedure.

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