PIK3C2G pAb

Phosphoinositide 3-kinase activity is implicated in assorted cellular responses activated by mammalian cell surface receptors and the regulation of protein sorting in yeast. The p110(gamma) (PIK3CG) enzyme is activated in vitro by both the (alpha) and (beta)(gamma) subunits of heterotrimeric GTP-binding proteins (G proteins) and does not associate with a p85 adaptor molecule. PI 3-kinase C2(gamma), also designated p110(gamma), may link signaling through G protein-coupled receptors to the generation of phosphoinositide second messengers that are phosphorylated in the D-3 position. The PI 3-kinase C2(gamma) gene encodes a 1,050 amino acid polypeptide with 36% identity to human PI 3-kinase C2(alpha). Research indicates that PI 3-kinase C2(gamma) can block the growth of human colon cancer cells.

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SPECIFICATIONS

Catalog Number

BS60313

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

A synthetic peptide corresponding to residues in Human PIK3C2G.

Species

PIK3C2G pAb detects endogenous levels of PIK3C2G protein.

Dilutions

WB: 1:500~1:1000\r

Swiss Prot

O75747

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 171 kDa

Alternative Names

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; PI3K-C2-gamma; Short name=PtdIns-3-kinase C2 subunit gamma; Phosphoinositide 3-kinase-C2-gamma; PI 3-kinase C2(gamma); PI3KC2(gamma)