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PKA II(alpha) reg (P68) pAb

PKA II(alpha) reg (P68) pAb

Cat no: BS1929

Supplier: Bioworld Technology, Inc.
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The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated C(alpha), C(beta) and C(gamma), that each represent specific gene products. C(alpha) and C(beta) are closely related (93% amino acid sequence similarity), where as C(gamma) displays 83% and 79% similarity to C(alpha) and C(beta), respectively. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the pol II transcription initiation complex.
Catalogue number: BS1929
Reactivities: Human
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P13861
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 50-100 of Human PKA II(alpha) reg.
Species: PKA II(alpha) reg (P68) pAb detects endogenous levels of PKA II(alpha) reg protein.
Molecular weight: ~ 45 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: PRKAR2A; PKR2; PRKAR2
Additional info: For research use only, not for use in diagnostic procedure.

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