PKAgamma cat (P5) Peptide

Cat no: BS1953P

Supplier: Bioworld Technology, Inc.

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Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated Calpha, Cbeta and Cgamma , that each represent specific gene products. Calpha and Cbeta are closely related (93% amino acid sequence similarity), whereas Cgamma displays 83% and 79% similarity to Calpha and Cbeta, respectively. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the Pol II transcription initiation complex.

Catalogue number:	BS1953P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P22612
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide PKAgamma cat (P5). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	cAMP-dependent protein kinase catalytic subunit gamma; KAPCG; KAPG; PKA C gamma; PKA C-gamma; PKACg; PRKACG; Protein kinase cAMP dependent catalytic gamma; Serine (threonine) protein kinase;
Additional info:	This peptide can be used with studies using BS1953 PKAgamma cat (P5) pAb.

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PKAgamma cat (P5) Peptide

Cat no: BS1953P

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