Platencin

Platencin is a more potent analogue of Platensimycin also discovered from a strain of Streptomyces platensis. Platencin shows potent in vivo efficacy without any observed toxicity. Platencin targets two essential proteins, b-ketoacyl-acyl carrier protein (ACP) synthase II (FabF) and III (FabH) whereas platensimycin targets only FabF.\n\nSource:\nPlatencin\n\nMolecular Weight:\n~425.2\n\nSolubility:\nSoluble in ethanol, methanol, DMF or DMSO.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

P4262

Size

100ug

Form

Supplied as a light tan solid.

Purity

(same/more than) 95% by HPLC

References

1. Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity. Jayasuriya, H., et al., Angew. Chem. Int. Ed. 46: 4684 (2007). 2. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Wang, J., et al., PNAS 104: 7612 (2007).