PLC (beta)3 (L532) pAb

A total of eight mammalian PLC isozymes have been described (PLC (beta)1, PLC (beta)2, PLC (beta)3, PLC (beta)4, PLC (gamma)1, PLC (gamma)2, PLC (delta)1 and PLC (delta)2) with molecular weights ranging from 85 to 150 kDa. The (gamma)-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two (gamma)-type enzymes, but not the (beta) and (delta) isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC (beta)1, PLC (beta)2 and PLC (beta)3 is mediated by the (alpha) subunits of the Gq class of heterotrimeric G proteins and by certain (beta)(gamma) G protein subunits. The regulatory mechanisms for PLC (delta)1 and PLC (delta)2 are as yet not resolved.

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SPECIFICATIONS

Catalog Number

BS1787

Size

100ug/100ul

Applications

IF, IHC

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 500-550 of Human PLC (beta)3.

Species

PLC (beta)3 (L532) pAb detects endogenous levels of PLC (beta)3 protein.

Dilutions

IHC: 1:50~1:200 \nIF: 1:50~1:200

Swiss Prot

Q01970

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 150 kDa

Alternative Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (beta)-3; Phosphoinositide phospholipase C-(beta)-3; Phospholipase C-(beta)-3; PLC-(beta)3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3; PLC-beta-3; PLCB3; PLC(beta)3