PLC (gamma)1 (G777) pAb

Cat no: BS1295

Supplier: Bioworld Technology, Inc.

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Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC (beta)1, PLC (beta)2, PLC (beta)3, PLC (beta)4, PLC (gamma)1, PLC (gamma)2, PLC (delta)1, PLC (delta)2 and PLC E. PLC (gamma)1 is widely distributed in bronchiolar epithelium, type I and II pneumocytes and fibroblasts of the interstitial tissue. Actinregulatory protein Villin is tyrosine phosphorylated and associates with PLC (gamma)1 in the brush border of intestinal epithelial cells. Villin regulates PLC (gamma)1 activity by modifying its own ability to bind phosphatidylinositol 4,5-biphosphate. PLC (gamma)1 binds (alpha)1(beta)1 Integrin and modulates (alpha)1(beta)1 Integrin-specific adhesion. PLC (gamma)1 and Ca2+ play a direct role in VEGF-regulated endothelial growth, however this signaling pathway is not linked to FGF-mediated effects in primary endothelial cells.

Catalogue number:	BS1295
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	P19174
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 740-790 of Human PLC (gamma)1.
Species:	PLCG1 (G777) pAb detects endogenous levels of PLCG1 protein.
Molecular weight:	~ 155 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; PLC148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C2; PLC2I; Phospholipase C-gamma-1; PLC-gamma-1; PLCG1; PLC1; PLC(gamma)1;
Additional info:	For research use only, not for use in diagnostic procedure.

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PLC (gamma)1 (G777) pAb

Cat no: BS1295

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