PLC gamma 1 (G777) Peptide

Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC beta1, PLC beta2, PLC beta3, PLC beta4, PLC gamma 1, PLC gamma 2, PLC delta1, PLC delta2 and PLC E. PLC gamma 1 is widely distributed in bronchiolar epithelium, type I and II pneumocytes and fibroblasts of the interstitial tissue. Actinregulatory protein Villin is tyrosine phosphorylated and associates with PLC gamma 1 in the brush border of intestinal epithelial cells. Villin regulates PLC gamma 1 activity by modifying its own ability to bind phosphatidylinositol 4,5-biphosphate. PLC gamma 1 binds alpha1beta1 Integrin and modulates alpha1beta1 Integrin-specific adhesion. PLC gamma 1 and Ca2+ play a direct role in VEGF-regulated endothelial growth, however this signaling pathway is not linked to FGF-mediated effects in primary endothelial cells.

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SPECIFICATIONS

Catalog Number

BS1295P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide PLC gamma 1 (G777). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P19174

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1295 PLC gamma 1 (G777) pAb.

Alternative Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; PLC148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C2; PLC2I; Phospholipase C-gamma-1; PLC-gamma-1; PLCG1; PLC1; PLCgamma 1;