PLK4 (Serine/threonine-protein Kinase PLK4, Polo-like Kinase 4, PLK-4, Serine/Threonine-protein Kinase 18, Serine/Threonine-protein Kinase Sak, SAK, STK18)

SAK is involved in regulation of cell cycle. SAK is a key regulator of centriole duplication.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:32,000\nWestern Blot: 1-3ug/ml, observed in Human Colon lysates on ~110kD bands\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P4275-15E

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum, Bov, Can

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Martindill DM, Risebro CA, Smart N, Franco-Viseras Mdel M, Rosario CO, Swallow CJ, Dennis JW, Riley PR. Nucleolar release of Hand1 acts as a molecular switch to determine cell fate. Nat Cell Biol. 2007 Oct;9(10):1131-41. 2. Syed N, Smith P, Sullivan A, Spender LC, Dyer M, Karran L, O'Nions J, Allday M, Hoffmann I, Crawford D, Griffin B, Farrell PJ, Crook T. Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies. Blood. 2006 Jan 1;107(1):250-6. Epub 2005 Sep 13.

Additional Info

Recognizes human PLK4. Species sequence homology: Bovine and canine.