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PML (P39) pAb

PML (P39) pAb

Cat no: BS1296

Supplier: Bioworld Technology, Inc.
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The PML protein is a zinc finger transcription factor expressed as three major transcription products due to alternative splicing. The gene encoding human PML maps to chromosome 15q22. The t(15;17) (q22;q11.2-q12) chromosomal trans-location of the retinoic acid receptor (alpha) (RAR(alpha)) gene occurs in virtually all cases of acute promyelocytic leukemia and results in the expression of a PML/RAR(alpha) chimeric protein. Myeloid precursor cells expressing the PML/ RAR(alpha) chimera fail to differentiate and exhibit an increased growth rate consequent to diminished apoptosis. PML/RAR(alpha) transforms myeloid precursors by recruiting the nuclear co-repressor (N-CoR)-histone deacetylase complex that is essential to retinoic acid-dependent myeloid differentiation. PML/ RAR(alpha) also recruits DNA methyltransferases in order to induce gene hypermethylation and silencing, which ultimately facilitates leukemogenesis.
Catalogue number: BS1296
Reactivities: Human
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P29590
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to the N-terminal of Human PML.
Species: PML (P39) pAb detects endogenous levels of PML protein.
Molecular weight: ~ 98 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: PML; MYL; PP8675; RNF71; TRIM19
Additional info: For research use only, not for use in diagnostic procedure.

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