PML pAb

Cat no: BS6223

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

The PML protein is a zinc finger transcription factor expressed as three major transcription products due to alternative splicing. The gene encoding human PML maps to chromosome 15q22. The t(15;17) (q22;q11.2-q12) chromosomal trans-location of the retinoic acid receptor (alpha) (RAR(alpha)) gene occurs in virtually all cases of acute promyelocytic leukemia and results in the expression of a PML/RAR(alpha) chimeric protein. Myeloid precursor cells expressing the PML/ RAR(alpha) chimera fail to differentiate and exhibit an increased growth rate consequent to diminished apoptosis. PML/RAR(alpha) transforms myeloid precursors by recruiting the nuclear co-repressor (N-CoR)-histone deacetylase complex that is essential to retinoic acid-dependent myeloid differentiation. PML/ RAR(alpha) also recruits DNA methyltransferases in order to induce gene hypermethylation and silencing, which ultimately facilitates leukemogenesis.

Catalogue number:	BS6223
Reactivities:	Human
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	P29590
Dilutions:	WB: 1:500~1:2000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Recombinant full length Human PML.
Species:	PML pAb detects endogenous levels of PML protein.
Molecular weight:	~ 98 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	MYL; PML; PML; PP8675; Probable transcription factor PML; Promyelocytic leukemia; Promyelocytic leukemia inducer of; Promyelocytic leukemia protein; Protein PML; RING finger protein 71; RNF 71; RNF71; TRIM 19; TRIM19; Tripartite motif containing protein 19; Tripartite motif protein TRIM19; Tripartite motif-containing protein 19;
Additional info:	For research use only, not for use in diagnostic procedure.

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PML pAb

Cat no: BS6223

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