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PNPO, Recombinant, Human (Pyridoxine-5'-phosphate Oxidase, Pyridoxamine-phosphate Oxidase)

Cat no: P4350-25


Supplier: United States Biological
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PNPO, also known as pyridoxine-5'-phosphate oxidase, is the rate-limiting enzyme in vitamin B6 synthesis. Vitamin B6, or pyridoxal 5-prime-phosphate (PLP), is critical for normal cellular function, and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts. Source: Recombinant corresponding to aa57-261 of human PNPO protein, fused to His-tag at N-terminus, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MDPVKQFAAW FEEAVQCPDI GEANAMCLAT CTRDGKPSAR MLLLKGFGKD GFRFFTNFES RKGKELDSNP FASLVFYWEP LNRQVRVEGP VKKLPEEEAE CYFHSRPKSS QIGAVVSHQS SVIPDREYLR KKNEELEQLY QDQEVPKPKS WGGYVLYPQV MEFWQGQTNR LHDRIVFRRG LPTGDSPLGP MTHRGEEDWL YERLAP Molecular Weight: 25.9kD (226aa) confirmed by MALDI-TOF (molecular size on SDS-PAGE will appear higher) Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: P4350-25
Size: 100ug
Form: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 10% glycerol, 0.1M sodium chloride, 0.1mM PMSF.
Purity: ~90% (SDS-PAGE).
References: 1. Ngo EO., et al. (1998), Biochemistry., 37(21):7741-8. 2. Kang JH., et al. (2004). Eur J Biochem., 271(12):2452-61.

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