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Podocin Peptide

Cat no: BS60405P

Podocin Peptide

The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.

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SPECIFICATIONS

Catalog Number

BS60405P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide Podocin. (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q9NP85

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS60405 Podocin pAb.

Alternative Names

NPHS2

SUPPLIER INFO

Bioworld Technology, Inc.

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