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POT1 (N296) Peptide

POT1 (N296) Peptide

Cat no: BS2933P

Supplier: Bioworld Technology, Inc.
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POT1 is a component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. It is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Pot1 also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. It binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Its activity is TERT dependent but it does not increase TERT activity.
Catalogue number: BS2933P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q9NUX5
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide POT1 (N296). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein; POT1
Additional info: This peptide can be used with studies using BS2933 POT1 (N296) pAb.

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