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PP1alpha (G315) Peptide

Cat no: BS1765P

PP1alpha (G315) Peptide

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunit have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP1 family is comprised of subfamily members PP1alpha, PP1beta and PP1gamma , which are 37 kDa MgATP-dependent enzymes. PP1 inactivity is maintained through its association with the 16-18 kDa inhibitory protein NIPP-1 (nuclear inhibitor of PP1). Phosphorylation of NIPP-1 by cAMP-PK or casein kinase II results in the release of active PP1.

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SPECIFICATIONS

Catalog Number

BS1765P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide PP1alpha (G315). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P62136

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1765 PP1alpha (G315) pAb.

Alternative Names

PPP1CA; EC 3.1.3.16; MGC15877; MGC1674; PP-1A; PPP1A

SUPPLIER INFO

Bioworld Technology, Inc.

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