PPP2R5A pAb

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A family comprises subfamily members PP2A(alpha) and PP2A(beta). The PP2A catalytic subunit associates with a variety of regulatory subunits. Regulatory subunits include PP2A-A-(alpha) and -A-(beta), PP2A-B-(alpha) and -B-(beta), PP2A-C-(alpha) and -C-(beta), PP2A-B56-(alpha), -B56-(beta), -B56-(gamma) and -B56-(delta).

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SPECIFICATIONS

Catalog Number

BS5863

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 363-408 of Human PPP2R5A.

Species

PPP2R5A pAb detects endogenous levels of PPP2R5A protein.

Dilutions

WB: 1:500~1:1000\nICC: 1:50~1:200

Swiss Prot

Q15172

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 56 kDa

Alternative Names

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; PP2A B subunit isoform B'-alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform PR61-alpha; PR61alpha; PP2A B subunit isoform R5-alpha; PP2A-B56-(alpha); PP2A-B56(alpha); PP2A B56-(alpha); PP2AB56(alpha); PR61(alpha); PP2A-B-PR61(alpha)