PPP4C mAb

Cat no: MB0060

Supplier: Bioworld Technology, Inc.

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Additional Information

Protein phosphatase 4C may be involved in microtubule organization. It binds 1 iron ion and 1 manganese ion per subunit. PP4 consists of a catalytic subunit PPP4C and a regulatory subunit. PPP4R1 and belongs to the PPP phosphatase family, PP X subfamily.Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity)

Catalogue number:	MB0060
Reactivities:	Human
Hosts:	Mouse
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	P60510
Dilutions:	WB: 1:1000 ICC: 1:50~200 IHC: 1:500
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Recombinant full length Human PPP4C.
Species:	This antibody detects endogenous levels of PPP4C and does not cross-react with related proteins
Molecular weight:	Predicted band size:34KDa Observed band size:34KDa
Purity:	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	PP4; PPX; PP4C; PPH3; PPP4; Protein Phosphatase 4C;
Additional info:	For research use only, not for use in diagnostic procedure.

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PPP4C mAb

Cat no: MB0060

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