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PRAS40 (P240) Peptide

Cat no: BS1504P

PRAS40 (P240) Peptide

Akt, also known as protein kinase B, is one of the major downstream targets of the phosphatidylinositol 3-kinase pathway. This protein kinase has been implicated in insulin signaling, stimulation of cellular growth, inhibition of apoptosis and transformation of cells. The proline-rich Akt substrate PRAS40, also designated AKT1S1, becomes phosphorylated by activated Akt on Ser or Thr residues in the motif RXRXX(S/T). Phosphorylated PRAS40 subsequently binds 14-3-3 in a sequence-specific manner, thereby inducing such changes as alteration of protein subcellular localization and regulation of intrinsic enzymatic activity. Studies also suggest that PRAS40 phosphorylation and its interaction with pAkt and 14-3-3 may play an important role in neuroprotection mediated by NGF in apoptotic neuronal cell death after cerebral ischemia. PRAS40 maps to human chromosome 19q13.33.

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SPECIFICATIONS

Catalog Number

BS1504P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide PRAS40 (P240). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q96B36

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1504 PRAS40 (P240) pAb.

Alternative Names

AKT1S1; LOBE; MGC2865; PRAS40; PROLINE-RICH

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