Home  >  Products  >  PRDM16 (PR Domain Zinc Finger Protein 16, PR Domain-containing Protein 16, Transcription Factor MEL1, MDS1/EVI1-like Gene 1, KIAA1675, MEL1, PFM13)
PRDM16 (PR Domain Zinc Finger Protein 16, PR Domain-containing Protein 16, Transcription Factor MEL1, MDS1/EVI1-like Gene 1, KIAA1675, MEL1, PFM13)

PRDM16 (PR Domain Zinc Finger Protein 16, PR Domain-containing Protein 16, Transcription Factor MEL1, MDS1/EVI1-like Gene 1, KIAA1675, MEL1, PFM13)

Cat no: P5750-80B

Supplier: United States Biological
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PRDM16, also known as Mel1, is a zinc finger protein that plays a role in the differentiation of brown adipose tissue, which plays a role in dissipating heat in response to cold or excess feeding. PRDM16 works together with CEBPB to regulate the differentiation of myoblastic precursors into brown adipose cells. PRDM16 is also a repressor of TGF beta signalling, interacting with SKI to promote the recruitment of the SMAD3-HDAC1 complex to the promoter of TGF beta target genes. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: P5750-80B
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Mochizuki N, Shimizu S, Nagasawa T, Tanaka H, Taniwaki M, Yokota J, Morishita K. A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells. Blood 2000 Nov 1;96(9):3209-14.
Additional info: Recognizes PRDM16. Species sequence homology: Human.

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