PRMT1 pAb

Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional acivity.

Prices direct from Bioworld Technology, Inc.

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

BS6106

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human PRMT1.

Species

PRMT1 pAb detects endogenous levels of PRMT1 protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

Q99873

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 42 kDa

Alternative Names

ANM 1; \nANM1; \nANM1; \ncomplete cds; \nHCP 1; \nHCP1; \nHeterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2; \nHeterogeneous nuclear ribonucleoproteins methyltransferase like 2; \nHeterogeneous nuclear ribonucleoproteins methyltransferase like2; \nHistone-arginine N-methyltransferase PRMT1; \nHMT 2; \nHMT1 (hnRNP methyltransferase; \nHMT1 (hnRNP methyltransferase S. cerevisiae) like 2; \nHMT1 hnRNP methyltransferase; \nHMT1 hnRNP methyltransferase like 2 (S. cerevisiae); \nHMT1 hnRNP met