Progranulin (mouse) BioAssay(TM) ELISA Kit (Proepithelin, PEPI, PC Cell-derived Growth Factor)

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. New cutting-edge publications have shown that progranulin might be a biomarker not only for FTLD, but also for other types of Alzheimer's disease (AD). This new data even supposes the potential of progranulin to be a biomarker for MCI (Mild Cognitive Impairment), which would be a hallmark in AD research. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: +4 degrees C

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SPECIFICATIONS

Catalog Number

045168

Size

96Tests

References

Product Reference: \n?Microglial upregulation of progranulin as a marker of motor neuron degeneration: T. Philips, et al.; J. Neuropathol. Exp. Neurol. 69, 1191 (2010)\n?Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3beta phosphorylation: T. Nedachi, et al.; Neuroscience 185, 106 (2011)\n?

Additional Info

Detects mouse progranulin. Does not cross-react with human progranulin.

Alternative Names

Proepithelin, PEPI, PC Cell-derived Growth Factor