Prolactin BioAssay(TM) ELISA Kit, Human

Sandwich ELISA quantitative detection kit for Human Prolactin in cell culture supernates, serum and plasma (heparin, citrate).\n\nProlactin, also calle PRL, is a protein that in humans is encodes by the PRL gene. This gene is mapped to 6p22.3. This gene encodes the anterior pituitary hormone prolactin. It may play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system. Prolactin has important cell cycle related functions as a growth-, differentiating- and anti-apoptotic factor. As a growth factor binding to cytokine like receptors it has also profound influence on hematopoiesis,angiogenesis and is involved in the regulation of blood clotting through several pathways.\n\nAssay Range:\n156pg/ml-10,000pg/ml\n\nSensitivity:\n< 10 pg/ml\n\nCrossreactivity:\nThere is no detectable cross-reactivity with other relevant proteins.\n\nUniprot ID:\nP01236\n\nEntrez Gene ID:\n5617\n\nKit Components:\n96-well plate pre-coated with anti-Prolactin, Human\nLyophilized recombinant Prolactin, Human standard, 10ng/tube, 2Ea\nUSB Cat No Kit Component\n143696 Avidin-Biotin-Peroxidase Complex (ABC), 130ul (1:100 dilution)\n143697 Sample diluent buffer, 30ml\n143698 Antibody diluent buffer, 12ml\n143699 ABC diluent buffer, 12ml\n143700 TMB color developing agent, 10ml\n143701 TMB stop solution, 10ml\n\nStorage and Handling:\nStore at 4 degrees C for 6 months, at -20 degrees C for 12 months. Avoid multiple freeze-thaw cycles.

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SPECIFICATIONS

Catalog Number

144015

Size

96Tests

References

1. Ge, G., Fernandez, C. A., Moses, M. A., Greenspan, D. S. Bone morphogenetic protein 1 processes prolactin to a 17-kDa antiangiogenic factor. Proc. Nat. Acad. Sci. 104: 10010-10015, 2007. \n2. Matsuda, M., Imaoka, T., Vomachka, A. J., Gudelsky, G. A., Hou, Z., Mistry, M., Bailey, J. P., Nieport, K. M., Walther, D. J., Bader, M., Horseman, N. D. Serotonin regulates mammary gland development via an autocrine-paracrine loop. Dev. Cell 6: 193-203, 2004.\n