PSME3 pAb

Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.

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SPECIFICATIONS

Catalog Number

BS6027

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human PSME3.

Species

PSME3 pAb detects endogenous levels of PSME3 protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

P61289

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 30 kDa

Alternative Names

11S regulator complex gamma subunit; \n11S regulator complex subunit gamma; \nActivator of multicatalytic protease subunit 3; \nKi; \nKi antigen; \nKi nuclear autoantigen; \nKi; PA28 gamma; \nPA28 gamma; \nPA28G; \nPA28gamma; \nProteasome (prosome; macropain) activator subunit 3 (PA28 gamma; Ki); \nProteasome (prosome; macropain) activator subunit 3; \nProteasome activator 28 gamma; \nProteasome activator 28 subunit gamma; \nProteasome activator complex subunit 3; \nProteasome activator subunit 3; \nPSME3; \nPS