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PTPN2 pAb

PTPN2 pAb

Cat no: BS6716

Supplier: Bioworld Technology, Inc.
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T-cell protein tyrosine phosphatase (TC-PTP) is a non-transmembrane enzyme. The noncatalytic domain of TC-PTP is alternatively spliced to generate p45TC, which localizes to the nucleus, and p48TC, which contains a hydrophobic C-terminal tail and localizes to the ER. The C-terminal segment of p45TC regulates the activity of the catalytic domain through an intramolecular interaction. The p45TC variant of TC-PTP exits the nucleus upon EGF receptor activation and recognizes the EGF receptor and p52Shc cellular substrates. The p45TC activity almost completely inhibits the EGF-dependent activation of PI 3-kinase and PKB/Akt. In glioblastoma cells, the p45TC variant inhibits the DEGFR-mediated activation of ERK2 and suppresses tumorigenicity in vivo. TC-PTP may play a role in lymphoctye signaling and hematopoietic homeostasis. TC-PTP negatively regulates JAK1 and JAK3 and TC-PTP-deficient mice display gross defects in the hematopoietic system. The gene encoding human TC-PTP maps to chromosome 18.
Catalogue number: BS6716
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P17706
Dilutions: WB: 1:500~1:2000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Recombinant full length Human PTPN2.
Species: PTPN2 pAb detects endogenous levels of PTPN2 protein.
Molecular weight: ~ 48 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Protein tyrosine phosphatase non receptor type 2; PTN2; PTPN 2; PTPN2; PTPT; T cell protein tyrosine phosphatase; TC PTP; TCELLPTP; Tyrosine protein phosphatase non receptor type 2;
Additional info: For research use only, not for use in diagnostic procedure.

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