PTPRN2 Peptide

Protein-Tyrosine Phosphatase Receptor-Type IA-2beta (PTP IA-2beta), alternately known as PTPRN2 or Phogrin, localizes in dense-core secretory vesicles of pancreas islet cells and influences insulin secretion. The PTP IA-2beta precursor is an autoantigen that contributes to insulin-dependent diabetes mellitus (IDDM). The autoantigenic epitopes of PTP IA-2beta appear within the cytoplasmic domain of this transmembrane protein. PTP IA-2beta is present at high levels in brain and pancreas with lower levels in trachea, prostate, stomach and spinal cord. The human PTPRN2 gene maps to chromosome 7q36. Northern blot analysis showed that PTPRN2 was expressed as 5.5- and 3.7-kb transcripts primarily in human brain and pancreas. Three alternative transcript splice variants of this gene encode distinct proteins.

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SPECIFICATIONS

Catalog Number

BS5871P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide PTPRN2. (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q92932

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS5871 PTPRN2 pAb.

Alternative Names

Receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; Islet cell autoantigen-related protein; IAR; ICAAR; Phogrin; KIAA0387; PTP IA-2beta; PTPIA-2beta; PTP-IA-2beta; PTP-IA2beta; PTP IA2beta