PUMA (R169) pAb

Cat no: BS2922

Supplier: Bioworld Technology, Inc.

0 reviews | Write a Review Pencil

Description
Additional Information

PUMA (Bcl-2 binding component 3, JFY1, PUMA/JFY1) is a mitochondrial pro-apoptotic Bcl-2 homology domain (BH3)-only protein that induces rapid apoptosis through a Bax- and mitochondria-dependent pathway. The PUMA gene encodes four proteins originating from different splice variants of the same transcript: PUMA(alpha), (beta), (gamma) and (delta). Both PUMA(alpha) and PUMA(beta) contain a BH3 domain, while PUMA(gamma) and PUMA(delta) lack this domain. The BH3 domain is essential for binding of PUMA(alpha) and PUMA(beta) to Bcl-2 or Bcl-xL. PUMA is an initiator of (gamma)-radiation apoptosis and glucocorticoid-induced apoptosis in lymphoid cells in vivo. Bcl-2 family members generally regulate apoptosis and transmit death signals to mitochondria. Members of this family include both pro- and anti-apoptotic proteins that share homologous sequences known as Bcl-2 homology domains (BH1-4). The BH3 proteins, BID, NOXA, PUMA, NBK, Bim and Bad, are all pro-apoptotic and share sequence homology within the amphipathic (alpha)-helical BH3 region.

Catalogue number:	BS2922
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Western Blot
Size:	100ug/100ul
Swiss prot:	Q9BXH1
Dilutions:	WB: 1:500~1:1000
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 132-183 of Human PUMA.
Species:	PUMA (R169) pAb detects endogenous levels of PUMA protein.
Molecular weight:	~ 20 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	BBC 3 antibody BBC3 antibody BCL 2 binding component 3 antibody BCL2 binding component 3 antibody JFY 1 antibody JFY1 antibody p53 up regulated modulator of apoptosis antibody p53 Upregulated Modulator of Apoptosis antibody PUMA alpha antibody PUMA/JFY1 antibody
Additional info:	For research use only, not for use in diagnostic procedure.

See Full Product Listings >

PUMA (R169) pAb

Cat no: BS2922

Get Quote

About Biosave

Product Categories

Information


Get a Quote Direct from Bioworld Technology, Inc.




By submitting this form you agree to your details being passed to Bioworld Technology, Inc. for the purpose of generating the best quote*