PVRL1 pAb

PVRL1 is a Ca2+-independent homophilic cell adhesion molecule that belongs to the immunoglobulin superfamily. Human PVRL1 is identical to the poliovirus receptor-related protein (PRR) and is identified to be the alphaherpesvirus entry mediator. PVRL1 constitutes a family consisting of at least PVRL1 1, 2 and 3. PVRL1 2 and 3 are ubiquitously expressed, whereas PVRL1 1 is abundantly expressed in the brain. PVRL1 1 exists as PVRL1 1(alpha) and 1(beta)/HIgR, produced by alternative splicing. The cytoplasmic regions of PVRL1 1(alpha), but not PVRL1 1(beta)/HIgR, have a C-terminal conserved motif (E/A-X-Y-V). This motif interacts with the PDZ domain of the F-Actin-binding protein, afadin, through which it is linked to the Actin cytoskeleton. PVRL1 1, also designated HveC/ PRR1, allows the entry of herpes simplex virus type 1 (HSV-1) and HSV-2 into mammalian cells. The interaction of virus envelope glycoprotein D (gD) with PVRL1 1 is an essential step in the process leading to membrane fusion; the gD binding site is located at the first Ig-like domain of PVRL1 1. Both the transinteraction of PVRL1 and the interaction of PVRL1 with afadin are necessary for their co-localization with E-cadherin and catenins at adherens junctions.

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SPECIFICATIONS

Catalog Number

BS6717

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human PVRL1.

Species

PVRL1 pAb detects endogenous levels of PVRL1 protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

Q15223

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 57 kDa

Alternative Names

CD111; CD111 antigen; CLPED1; ectodermal dysplasia 4 (Margarita Island type); ED4; Herpes virus entry mediator C; Herpesvirus entry mediator C; Herpesvirus Ig like receptor; Herpesvirus Ig-like receptor; HIgR; HveC; MGC142031; Nectin 1; Nectin-1; OFC7; OROFACIAL CLEFT 7; OTTHUMP00000232093; OTTHUMP00000232094; OTTHUMP00000232095; Poliovirus receptor related protein 1; poliovirus receptor-like 1; Poliovirus receptor-related protein 1; PRR; PRR1; PVRL 1; PVRL1; PVRL1; PVRR; PVRR1; SK-12;