Rabies

Rabies virus is a Lyssavirus that causes rabies in mammals. The virus is found in the saliva of infected animals and is mostly spread though bites. The virus then travels though the peripheral nervous system to the central nervous system. Once it reaches the brain it causes acute encephalitis. Symptoms include paralysis, cerebral dysfunction, anxiety, insomnia, confusion, anger, paranoia, terror and hallucination. The production of a large amount of saliva, the inability to speak or swallow and associated hydrophobia is also common in the later stages of the disease. The time between exposure to the virus and onset of symptoms can range from about 2 weeks to several months. Once symptoms appear, death is virtually inevitable. However, the disease can be effectively treated by post-exposure prophylaxis, through vaccination, provided this is done as soon as possible.\n\nApplications: \nSuitable for ELISA and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilutions:\nOptimal dilutions to be determined by the researcher.\n\nAffinity Constant: \n3.0x10e10L/mole\n\nSource: \nAscites\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

R0010

Size

1mg

Applications

ELISA, IHC

Hosts

Mouse

Form

Supplied in PBS, pH 7.4, 0.1% sodium azide.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG2a

References

1. Macikova, I., et al., Common and different antigenic properties of the rabies virus glycoprotein of strains SAD-Vnukovo and Pitman-Moore. Acta. Virol. 36(6): 541-550 (1992).\n2. Drew WL (2004). \"Chapter 41: Rabies\". In Ryan KJ, Ray CG (editors). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 597

Additional Info

Recognizes glycoprotein of over 20 strains of the rabies virus.