Rabphilin-3A (P231) Peptide

Cat no: BS1590P

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

The carboxy-terminal of rabphilin-3A consists of two C2 domains, A and B,and the amino-terminal (residues 45-170) contains a cysteine-rich rich region with two zinc finger motifs. Rabphilin-3A belongs to a family of other carboxyterminal type (C-type) tandem C2 proteins, which includes synaptotagmins and Doc2. Rabphilin is expressed in neuroendocrine cells and co-localizes with Rab3A on synaptic vesicles and chromaffin granules. Rabphilin-3A binds Rab3a/GTP/Mg+ within amino-terminal residues 45 and 170. Rabphilin-3A binds calcium ions and phosphatidylinositol 4,5-bisphophate containing lipid vesicles within its C2 domains. Rabphilin-3A is a positive regulator of calcium dependent exocytosis, while Rab3a is a negative regulator of exocytosis. Although rabphilin-3A associates with Rab3a, they seem to influence exocytosis independently of each other. Rabphilin-3A effects are likely mediated through interactions with an unknown factor that recognizes the Rab3 binding domain.

Catalogue number:	BS1590P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P47708
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Rabphilin-3A (P231). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	; Exophilin-1; Rabphilin 3A; KIAA0985
Additional info:	This peptide can be used with studies using BS1590 Rabphilin-3A (P231) pAb.

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Rabphilin-3A (P231) Peptide

Cat no: BS1590P

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