RASA1, CT (RASA1, RASA, Ras GTPase-activating protein 1, Ras p21 protein activator, p120GAP) (FITC)

The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze FITC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

040842-FITC

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to FITC.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Hemerly, J.P., et al. Eur. J. Endocrinol. 163(5):747-755(2010)\nWiemels, J.L., et al. Blood Cells Mol. Dis. 45(3):186-191(2010)\nBachas, C., et al. Blood 116(15):2752-2758(2010)\nOinuma, I., et al. J. Biol. Chem. 285(36):28200-28209(2010)\nAnand, S., et al. Nat. Med. 16(8):909-914(2010)

Additional Info

Human

Alternative Names

RASA1, RASA, Ras GTPase-activating protein 1, Ras p21 protein activator, p120GAP